A retrospective, multicenter, cross-sectional analysis of 793 patients with EoE (including adults and children) registered at 5 tertiary care centers in the United States has investigated whether there is any associations between race or gender and clinical presentation, endoscopic features, and histological findings in patients with EoE of various racial backgrounds.
According to this research, a significantly larger proportion of Caucasians than African Americans or other races had dysphagia (74%, 56%, and 53%, respectively; P<.001), food impaction (35%, 13%, and 13%, respectively; P<.001) and features of EoE that included rings (46%, 25%, and 18%, respectively; P<.001) or furrows (70%, 58%, and 55%, respectively; P=.012). This observation underscores the repeatedly documented predominance of EoE in Caucasian subjects. In fact, EoE was firstly described in patients from regions from US and Europe were Caucasians constitutes the majority of the population. Additionally, the frequency of EoE has been analyzed in several populations, and it resulted the highest in Caucasian subjects.
The aforementioned study, which has been authored by Dr Fouad J Moawad and colleagues, also documented that a higher proportion of male than female patients had strictures (17% vs 11%; P=.038), which means EoE trends to behave more aggresively in male patients.
The causes for these differences should be further evaluated.
Read the full paper at http://www.ncbi.nlm.nih.gov/pubmed/26343181